The local fire and rescue service received hundreds of flood-related calls on Friday night as heavy rain and melting snow combined to cause major distruption in parts of the county.
Drivers were faced with perilous conditions on the county's roads, with the A477 closed at the A40 interchange to Kilgetty and the A487 between Haverfordwest and St Davids also falling foul of the conditions.
A Pembrokeshire County Council spokesman said it had been "inundated with calls" with crews distributing sandbags to households throughout the weekend and clearing roads of floodwater.
The council said the worst affected areas in the north were Solva, Castlemorris, Mathry and St Nicholas, with Narberth, Clarbeston Road, Rosemarket, Angle and Milford Haven also hit.
Mid and West Wales Fire and Rescue Service said more than 50 properties were either affected by or threatened by floodwater after the River Solva burst its banks on Friday night.
Twenty-five firefighters from Haverfordwest, Milford Haven and St Davids assisted members of the public and pumped away the heavy volume of water.
A fire service spokesman said many residents had minimised the potential threat to their homes through proactive preparation.
Craig Thomas, station manager said: "Over the last three or four years this seems to be happening on quite a regular basis now where a long downpour of rain will hold over an area for quite some time causing significant flooding.
"And, of course, with the snow that we've had over the past week, that was also melting when the rain was coming down and the ground conditions were also very hard, so the water was running off the mountains and hills quite easily as well.
"We have got to the stage where we are well prepared for flooding incidents now, but we do still need the public to be as well prepared as possible, especially as we do expect more trouble."
The Monday Fishguard to Rosslare ferry crossing was cancelled due to adverse weather conditions and Tuesday's early morning crossing was also said to be "in doubt."
The Met Office has issued a yellow severe weather warning for more rain across Wales on Tuesday, advising people of the risk of further localised flooding with rainfall set to fall throughout the day.